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:: Volume 21, Issue 3 (8-2019) ::
J Mil Med 2019, 21(3): 243-250 Back to browse issues page
Comparison of Anti Thyroid Peroxidase Antibody (TPOAb) levels in people with depression and healthy people: case control-study
Mahboobeh-Sadat Hosseini, Shokofeh Radfar, Hamid Ghobadipour, Majid Ramezani *
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , m_ramezani@sina.tums.ac.ir
Abstract:   (311 Views)
Background and Aim: Depression is a common psychiatric disorder with a high prevalence in military personnel. Recently, the relationship between depression and some hormones has been reported. In current study, the serum levels of anti-thyroid peroxidase (anti-TPO), triiodothyronine (T3), thyroxin (T4) and thyroid-stimulating hormone (TSH) was assessed in people with depression and compared with healthy control adults.
Methods: In this case–control study, 45 people with depression who were diagnosed using the Beck depression test and DSM5, were referred to a military hospital. A total of 45 healthy participants who were matched according gender and age with the depression group, were also enrolled. Levels of anti-TPO, T4, T3 and TSH were measured and compared in the two groups.
Results: The mean ±standard deviation age was 36.55±11.42 years in the case group and 35.92±11.58 years in the matched control group. There was no significant difference in the mean serum level of antithyroid peroxidase, T3, T4 and TSH between the groups (P≥0.05). There was no linear correlation between antithyroid peroxidase levels and depression severity. 
Conclusion: As there was not difference regarding anti-TPO antibody levels between the depressed and healthy groups, it appears that anti-TPO antibody may not have a role in depression.
Keywords: Antithyroid Peroxidase, Depression, Thyroxin.
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Type of Study: Orginal Research | Subject: military medcine
Received: 2018/09/30 | Accepted: 2019/05/13
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Hosseini M, Radfar S, Ghobadipour H, Ramezani M. Comparison of Anti Thyroid Peroxidase Antibody (TPOAb) levels in people with depression and healthy people: case control-study. J Mil Med. 2019; 21 (3) :243-250
URL: http://militarymedj.ir/article-1-2046-en.html


Volume 21, Issue 3 (8-2019) Back to browse issues page
مجله طب‌نظامی Journal Mil Med
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