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Hastening the Sciatic Nerve Recovery through Inhibitation of TNF-α by the Etanercept
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| Fatemeh Basiri, Abbas ali Imani fooladi, Ghasem Bagherpoor, Hamideh Mahmoodzadeh hosseini, Foroutan Koudehi, Mohammad Reza Nourani * |
| baghyatalah university , r.nourani@yahoo.com |
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Abstract: (10891 Views) |
| Aims: As a result of Axonal cruch in peripheral nervous system, extensive and complicated pathways of cytokines are activated. The most important member of these pathways is TNF-α, that is a pro-inflammatory cytokine which its concentration influences on nerve recovery. It is probable that the nerve recovery quickens after employing inhibitors of this protein.
Methods: In this research 110 rats are categorized into 2 experimental and control groups. . Immediately after crushing the sciatic nerve, 0.6 mg/Kg of Etanercept was injected to each rat in experimental groups’, interaperitoneally. Saline was also used as a control which was injected to control rats.
Results: TNF-α expression extremely increased after nerve crush and Etanercept usage significantly reduced TNF-α expression, a day after nerve crush (p˂0.001). Nerve recovery based on immunohistochemistry and morphological observations in experimental group was better than the else by comparison.
Conclusion: The results suggests that the use of TNF- α’s antagonist after the injury can inhibit TNF-α expression and thereby hastening the nerve recovery. |
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| Keywords: TNF-α, Nerve Crush, Etanercept |
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Full-Text [PDF 878 kb]
(54593 Downloads)
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Type of Study: Orginal Research |
Subject:
military medcine
Received: 2012/06/20 | Accepted: 2013/09/9 | Published: 2013/09/9
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