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:: Volume 15, Issue 2 (Summer 2013) ::
J Mil Med 2013, 15(2): 125-132 Back to browse issues page
Hastening the Sciatic Nerve Recovery through Inhibitation of TNF-α by the Etanercept
Fatemeh Basiri, Abbas ali Imani fooladi, Ghasem Bagherpoor, Hamideh Mahmoodzadeh hosseini, Foroutan Koudehi, Mohammad Reza Nourani *
baghyatalah university , r.nourani@yahoo.com
Abstract:   (10891 Views)
Aims: As a result of Axonal cruch in peripheral nervous system, extensive and complicated pathways of cytokines are activated. The most important member of these pathways is TNF-α, that is a pro-inflammatory cytokine which its concentration influences on nerve recovery. It is probable that the nerve recovery quickens after employing inhibitors of this protein. Methods: In this research 110 rats are categorized into 2 experimental and control groups. . Immediately after crushing the sciatic nerve, 0.6 mg/Kg of Etanercept was injected to each rat in experimental groups’, interaperitoneally. Saline was also used as a control which was injected to control rats. Results: TNF-α expression extremely increased after nerve crush and Etanercept usage significantly reduced TNF-α expression, a day after nerve crush (p˂0.001). Nerve recovery based on immunohistochemistry and morphological observations in experimental group was better than the else by comparison. Conclusion: The results suggests that the use of TNF- α’s antagonist after the injury can inhibit TNF-α expression and thereby hastening the nerve recovery.
Keywords: TNF-α, Nerve Crush, Etanercept
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Type of Study: Orginal Research | Subject: military medcine
Received: 2012/06/20 | Accepted: 2013/09/9 | Published: 2013/09/9
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basiri F, imani fooladi A A, bagherpoor G, mahmoodzadeh hosseini H, Foroutan Koudehi, Nourani M R. Hastening the Sciatic Nerve Recovery through Inhibitation of TNF-α by the Etanercept. J Mil Med. 2013; 15 (2) :125-132
URL: http://militarymedj.ir/article-1-1017-en.html


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Volume 15, Issue 2 (Summer 2013) Back to browse issues page
مجله طب‌نظامی Journal Mil Med
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