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:: Volume 15, Issue 3 (Fall 2013) ::
J Mil Med 2013, 15(3): 215-218 Back to browse issues page
A novel model of inducing chronic osteomyelitis in rabbits
Morteza Izadi, Ali Jazayeri *, Mohammad reza Baghban eslami, Shahrbanoo Jahangir, Saeed Khodayari, Hamid Khodayari, Aziz Abbaspour, Amir pejman Hashemi taheri, Abbas Ali Imani fooladi, Nemat allah Joneidi, Ali mohammad Alizadeh
student research center, Tehran University of Medical Sciences, Tehran, Iran , alijazayer@gmail.com
Abstract:   (10920 Views)
Aims: Osteomyelitis is one of common diseases in Iran due to trauma, especially during war time. There is a variety of treatment methods for osteomyelitis. In this study we have tried to design a new animal model which is similar to human disease for future use as a standard model through studies. Methods: staphylococcus aureus was used to induce osteomyelitis in 24 rabbits’ tibia. We performed radiologic assessments on days 0, 14 and 28 after surgery. Bacteriologic studies and pathologic assessment were done on the 28th day too. Results: At the end of 4th week, more than 95% of animals showed radiologic signs of osteomyelitis. In pathological studies, invasion of inflammatory cells and other signs of osteomyelitis were seen. Conclusion: This modeling method can be used for study of osteomyelitis whereby comparing different antibiotics or scaffolds and stem cells.
Keywords: osteomyelitis, rabbit, staphylococcus aureus
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Type of Study: Orginal Research | Subject: military medcine
Received: 2013/06/13 | Accepted: 2013/11/24 | Published: 2013/11/24
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izadi M, jazayeri A, baghban eslami M R, jahangir S, khodayari S, khodayari H, et al . A novel model of inducing chronic osteomyelitis in rabbits. J Mil Med. 2013; 15 (3) :215-218
URL: http://militarymedj.ir/article-1-1159-en.html


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Volume 15, Issue 3 (Fall 2013) Back to browse issues page
مجله طب‌نظامی Journal Mil Med
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