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:: Volume 8, Issue 4 (Winter 2007) ::
J Mil Med 2007, 8(4): 291-296 Back to browse issues page
Side Effects of Low Dose and Long Term Erythromycin in Treatment of Sulfur Mustard-Induced Bronchiolitis Obliterans
Panahi Y. *, Ghanei M., Aslani J., Saeedfar H. R., Asari Sh.
, yunespanahi@bmsu.ac.ir
Abstract:   (37007 Views)

Introduction. Bronchiolitis Obliterans (BO) is known as a side effect of sulfur mustard (SM) exposure. Long term prescription of low dose macrolides has been found to be effective in BO. There is no report on the side effects of these drugs on sulfur mustard-induced BO. We compared the side effects of Erythromycin (EM), a member of macrolide family, with low-doses (400 mg daily) for 6 months versus placebo in treatment of BO induced by S M.

Material and Methods. This study was a double blind clinical trial carried out in Chemical Injuries Research Center of Baqyatallah (a.s.)

University of

Medical Sciences. 120 SM- induced BO patients were categorized randomly in group 1 (n=60, EM 400 mg daily) and group 2 (n=60, Placebo). Patients received EM or placebo during a 6-month period. Side effects such as headache, maculopapular rash, pharyngitis, nausea, diarrhea, abdominal pain, dizziness, vomiting, fever and icter were assessed and compared in both groups before and after treatment.

Results. The most common side effects in group 1 were pharyngitis (36.36%) and headache (36.36%), and in group 2 pharyngitis (37.50%) and maculopapular rash (37.50%). The prevalence of headache, abdominal pain, icter, dizziness, vomiting and diarrhea in group 1 was more than group 2 (p<0.05).

Discussion. According to the previous studies which demonstrated severity of side effects of EM resulted in decreasing use of it and its therapeutic outcomes, it is recommended to use other macrolides like clarythromycin and azythromycin in Bronchiolitis Obliterans due to sulfur mustard. 

Keywords: Bronchiolitis Obliterans, Side effect, Sulfur Mustard, Erythromycin, Macrolide.
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Type of Study: Orginal Research | Subject: military medcine
Received: 2007/07/15 | Published: 2007/01/15
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Panahi Y., Ghanei M., Aslani J., Saeedfar H. R., Asari Sh.. Side Effects of Low Dose and Long Term Erythromycin in Treatment of Sulfur Mustard-Induced Bronchiolitis Obliterans. J Mil Med. 2007; 8 (4) :291-296
URL: http://militarymedj.ir/article-1-389-en.html


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Volume 8, Issue 4 (Winter 2007) Back to browse issues page
مجله طب‌نظامی Journal Mil Med
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